study about Azithromycin

 

Azithromycin

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About this antibiotic?

content

     · Drug Class &Brand Name

     · Clinical Uses

     · Mechanism of action

     · Key side effects

     · Summary

 Drug Class

·                       ·   Antibiotic                     

·                      · Macrolide

 Brand Name

     ·    Zithromax

Clinical Uses

·    Active against gram-positive, gram- negative and atypical organisms.

·    Some common usages include:

·     Chronic obstructive pulmonary disease

(COPD) acute exacerbation.

·     Mycobacterium avium complex

 (MAC) infection.

·    Community acquired pneumonia

(CAP).

·    Sexually transmitted infections (STD)

 

Mechanism of action

1.      Bind to the 50S subunit of bacterial Ribosome

2.      Inhibit the translation of mRNA

3.      Blockage of transpeptidation

4.      Inhibit the protein synthesis

5.      Prevent bacteria from growing

Key side effects (1)

  ·    Altered cardiac conduction

·    Inhibit the delayed rectifier potassium Channel

·     Prolong the action potential of cardiac myocytes & the QT interval

   ·    Clostridioides difficile infection

·    May start on the first day of antibiotic therapy or up to 3 months post antibiotic. 

Key side effects (2)

·    Drug-induced liver injury:

·    Cause conditions like cholestatic hepatitis, hepatocellular hepatitis, etc.

·    Most patients fully recover after discontinuation of antibiotics.

·    Ototoxicity:

·    Linked to cumulative doses of Azithromycin.

·    Usually occur in prolonged prolonged duration of therapy (>4 weeks).

 

Summary

·    Azithromycin is an antibiotics under macrolide class that is active against G+, G- and atypical organisms.

·    It works by binding to 50S subunit of bacterial ribosome, thus blocking protein synthesis.

·    Some key side effect to pay attention include altered cardiac conduction, drug-induced liver toxicity and ototoxicity.