Valerian (valeriana officinalis) · Part used : Whole underground parts, including the rhizome surrounded by the roots and stolon’s. Constituents : a) 1-Volatile oils 0.5-2% : NLT 0.5% of volatile oil, and NLT 0.17% of total valerenic acids, calculated on the dried basis. b) 2- Iridoids (valepotriates) : Valerates, didrovaltrates and isovalerates groups. The valepotriates are unstable and decompose on storage or processing. Note : valerian is preferably to be administered as a herb tea or well-preserved pharmaceutical products. c) 3- Alkaloids (Pyridine type): e.g. valerianine and valerine. d) 4- Other constituents : Amino acids (e.g. arginine, y- aminobutyric acid (GABA) which argued if small or substantial amount can pass BBB (R3) , caffeic and chlorogenic acids (polyphenolic). Active Constituents: The sedative activity attributed to both the volatile oil and iridoid valepotriate (highly unstable) and GABA, also the other unknown compounds may c